×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
19638433 2009
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
17709330 2007
×
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Urinary excretion of bilirubin oxidative metabolites in arsenite-treated mice.
22688006 2012
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha.
21984482 2012
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Prediction of drug-induced liver injury using keratinocytes.
28138970 2017
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385 1995
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
9696492 1998
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
20623750 2011
×
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.
18227147 2008
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500
Therapeutic
CTD_human
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
19164858 2009
×
Entrez Id: 3565
Gene Symbol: IL4
IL4
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
IL-4 mediates dicloxacillin-induced liver injury in mice.
21094227 2011
×
Entrez Id: 50616
Gene Symbol: IL22
IL22
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation.
15122762 2004
×
Entrez Id: 6649
Gene Symbol: SOD3
SOD3
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
EC-SOD gene therapy reduces paracetamol-induced liver damage in mice.
11529661 2002
×
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor.
30215777 2019
×
Entrez Id: 2947
Gene Symbol: GSTM3
GSTM3
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.
25743375 2015
×
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
22491424 2012
×
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism.
20709802 2010
×
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.
19797606 2010
×
Entrez Id: 83667
Gene Symbol: SESN2
SESN2
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Sestrin2 protects against acetaminophen-induced liver injury.
28209544 2017
×
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation.
22627062 2012
×
Entrez Id: 256297
Gene Symbol: PTF1A
PTF1A
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Adaptive gene regulation of pyruvate dehydrogenase kinase isoenzyme 4 in hepatotoxic chemical-induced liver injury and its stimulatory potential for DNA repair and cell proliferation.
21182459 2011
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
7532385 1995
×
Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity.
30393195 2019
×
Entrez Id: 2328
Gene Symbol: FMO3
FMO3
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.
24973094 2014
×
Entrez Id: 2321
Gene Symbol: FLT1
FLT1
Chemical and Drug Induced Liver Injury
0.300
Therapeutic
CTD_human
Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity.
21135413 2011